| City | Region | Population | Latitude | Longitude |
|---|---|---|---|---|
| Mbocayaty | Guairá | 2,296 | -25.7193800 | -56.4217900 |
| Caapucú | Paraguarí | 2,284 | -26.2352300 | -57.1821200 |
| Natalio | Itapúa | 2,252 | -26.7570200 | -55.1377700 |
| Guayaybi | San Pedro | 2,247 | -24.5333300 | -56.4333300 |
| San Cosme y Damián | Itapúa | 2,223 | -27.3174100 | -56.3308700 |
| Mbuyapey | Paraguarí | 2,201 | -26.2192100 | -56.7577700 |
| Naranjal | Alto Paraná | 2,151 | -25.9666700 | -55.1833300 |
| Santiago | Misiones | 2,144 | -27.1431000 | -56.7680300 |
| Santa María | Misiones | 2,095 | -26.7833300 | -56.9333300 |
| Yhú | Caaguazú | 2,092 | -25.0500000 | -55.9166700 |
| Colonia San Lorenzo | Itapúa | 2,000 | -26.4932400 | -54.7998900 |
| Doctor Cecilio Báez | Caaguazú | 1,977 | -25.0500000 | -56.3166700 |
| Sapucaí | Paraguarí | 1,932 | -25.6665200 | -56.9521500 |
| Natalicio Talavera | Guairá | 1,809 | -25.6333300 | -56.3000000 |
| Colonia Minga Porá | Alto Paraná | 1,770 | -24.8666700 | -54.9000000 |
| Pirapó | Itapúa | 1,756 | -26.8601200 | -55.5435700 |
| San Joaquín | Caaguazú | 1,745 | -25.0285300 | -56.0428000 |
| Edelira | Itapúa | 1,698 | -26.7673400 | -55.2787200 |
| Unión | San Pedro | 1,653 | -24.8079000 | -56.5214800 |
| Itapé | Guairá | 1,641 | -25.8500000 | -56.6166700 |
| Caraguatay | Cordillera | 1,637 | -25.2384400 | -56.8269300 |
| Belén | Concepción | 1,621 | -23.4661100 | -57.2619400 |
| Buena Vista | Caazapá | 1,580 | -26.1833300 | -56.0833300 |
| Independencia | Guairá | 1,575 | -25.6910000 | -56.2678100 |
| General Delgado | Itapúa | 1,544 | -27.0904600 | -56.5247400 |
| Isla Pucú | Cordillera | 1,529 | -25.3085300 | -56.8998600 |
| San Patricio | Misiones | 1,525 | -26.9666700 | -56.8166700 |
| Carlos Antonio López | Itapúa | 1,496 | -26.4000000 | -54.7666700 |
| San Juan del Paraná | Itapúa | 1,492 | -27.3016800 | -55.9650900 |
| Mbutuý | Caaguazú | 1,466 | -24.9751800 | -56.3092700 |
| General Higinio Morínigo | Caazapá | 1,399 | -25.9500000 | -55.9166700 |
| Yataity del Norte | San Pedro | 1,392 | -24.8333300 | -56.3500000 |
| Corpus Christi | Canindeyú | 1,387 | -24.0804000 | -54.9393300 |
| Coronel Martínez | Guairá | 1,359 | -25.7500000 | -56.6166700 |
| General José Eduvigis Díaz | Ñeembucú | 1,345 | -27.2013600 | -58.3674000 |
| San Miguel | Misiones | 1,210 | -26.5000000 | -57.0500000 |
| Nueva Germania | San Pedro | 1,206 | -23.9000000 | -56.5666700 |
| Capitán Pablo Lagerenza | Alto Paraguay | 1,200 | -19.9166700 | -60.7833300 |
| Yegros | Caazapá | 1,140 | -26.4500000 | -56.4000000 |
| Santa Elena | Cordillera | 1,137 | -25.4132700 | -56.7970800 |
| Cerrito | Ñeembucú | 1,036 | -27.3421500 | -57.6411900 |